The kinase domain of RIPK3 tunes its scaffolding functions
Shene Chiou, Christopher R. Horne, Komal M. Patel, Adele Preaudet, James A. Rickard, Samuel N. Young, Asha Jois, Sarah E. Garnish, Anne Hempel, Cathrine M. Hall, Joanne M. Hildebrand, Andrew J. Kueh, John Silke, Tracy L. Putoczki, Edwin D. Hawkins, , James M. Murphy
This study compares three RIPK3 kinase-dead variants to show that their scaffolding functions differ based on kinase domain conformation, not just kinase activity, and highlights implications for inhibitor development.
Cell Death and Differentiation · Feb 3, 2026Peer-reviewedBiochemistry