Edwin D. Hawkins

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

This study identifies dysregulated epithelial cell death signaling in inflammatory bowel disease, showing it persists during remission despite therapy.

Menin regulates oncogenic cell identity transcriptional networks in multiple myeloma

This study identifies Menin as a key regulator of oncogenic gene expression in multiple myeloma and shows that Menin inhibitors are effective in myeloma cell lines and models.

CDK9 interacts with a RanGTP-NEMP1-Importin-β complex to regulate erythroid enucleation

This study identifies CDK9's interaction with a RanGTP-NEMP1-Importin-β complex in erythroid enucleation and shows that importin-β inhibition blocks enucleation.

The kinase domain of RIPK3 tunes its scaffolding functions

This study compares three RIPK3 kinase-dead variants to show that their scaffolding functions differ based on kinase domain conformation, not just kinase activity, and highlights implications for inhibitor development.

A PP2A-Integrator complex fine-tunes transcription by opposing CDK9

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.