Zhen Wang

The paper develops a chemoinformatics platform to discover RNA-binding small molecules, identifying ligands for the r(CUG)exp RNA in DM1 with splicing rescue activity.

This study investigates how different small molecules affect riboswitch activity by altering RNA conformation, showing distinct mechanisms in live cells.

This paper reports NMR structures and magnetic force spectroscopy studies of small molecules binding to RNA CAG repeat expansions, revealing their binding modes and structural effects.

This study shows that loss of H3.1K27me1 in Arabidopsis leads to resistance against Geminivirus by sequestering DNA repair proteins to defense genes and rDNA, reducing viral replication.

The paper uses spliceosome iCLIP to map human spliceosome engagement with snRNAs and pre-mRNAs, identifying over 50,000 branchpoints and their associated splicing factor binding patterns.