Genome wide screen of RNAi molecules against SARS-CoV-2 creates a broadly potent prophylaxis
Ohad Yogev, Omer Weissbrod, Giorgia Battistoni, Dario Bressan, Adi Naamti, Ilaria Falciatori, Ahmet Can Berkyurek, Roni Rasnic, Myra D.T. Hosmillo, Shaul Ilan, Iris Grossman, Lauren McCormick, Christopher Cole Honeycutt, Timothy S. Johnston, Matthew Gagné, , Yaniv Erlich
The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.
bioRxiv · Apr 12, 2022 · PreprintGenomics