Ahmet Can Berkyurek

Genome wide screen of RNAi molecules against SARS-CoV-2 creates a broadly potent prophylaxis

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.

A scalable pipeline for SARS-CoV-2 replicon construction based on de-novo synthesis

The paper describes a scalable pipeline for constructing SARS-CoV-2 replicons using de-novo synthesis, demonstrating their safety and utility for drug testing.

The RNA Polymerase II core subunit RPB-9 directs transcriptional elongation at piRNA loci in Caenorhabditis elegans

This study identifies RPB-9 as essential for piRNA-mediated silencing in C. elegans by promoting transcriptional elongation/termination at piRNA loci.

The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans

The paper identifies the USTC complex as essential for piRNA transcription in C. elegans, revealing its role in genome defense through specific binding to piRNA clusters.

The Aquarius/EMB-4 helicase licenses co-transcriptional gene silencing

This study identifies the Aquarius/EMB-4 helicase as essential for initiating small RNA-induced co-transcriptional gene silencing in C. elegans by facilitating HRDE-1 complex engagement with nascent transcripts.