Adriana Marques-Carvalho

This study investigates how mitochondrial reactive oxygen species (mtROS) affect bone mesenchymal cells, showing impaired mitochondrial function and NAD+ levels, and suggests combined therapies targeting mtROS, senescence, and NAD+ may delay age-related osteoporosis.

This study shows that increasing autophagy in osteoblast lineage cells via CRISPR activation of Tfeb improves bone mass and strength in mice.

This study shows estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts, reducing bone resorption through suppression of SIRT3 activity.