PhysiologyJCI InsightPeer-reviewed
CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Alicen James, James A. Hendrixson, Ilham Kadhim…·Melda Onal
This study shows that increasing autophagy in osteoblast lineage cells via CRISPR activation of Tfeb improves bone mass and strength in mice.
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