Maria Almeida

Targeting cellular senescence alleviates bone marrow aging

This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.

A transcriptomic-driven segmentation and cell simulation framework for high-resolution spatial transcriptomics and cell-cell communication

TENGU improves spatial transcriptomics by using transcript-signal density for cell segmentation and simulation, enhancing accuracy in complex tissues.

Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells

This study investigates how mitochondrial reactive oxygen species (mtROS) affect bone mesenchymal cells, showing impaired mitochondrial function and NAD+ levels, and suggests combined therapies targeting mtROS, senescence, and NAD+ may delay age-related osteoporosis.

CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength

This study shows that increasing autophagy in osteoblast lineage cells via CRISPR activation of Tfeb improves bone mass and strength in mice.

Estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts

This study shows estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts, reducing bone resorption through suppression of SIRT3 activity.

A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone

This study creates a harmonized atlas of murine bone-associated cells using single-cell RNA sequencing to clarify cell type designations and identify osteoblast progenitors.

Mmp-13 deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice