Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in CFH Y402H Patient-Derived Choriocapillaris Endothelial Cells
Agata L. Rozanska, Jasenka Guduric‐Fuchs, Varun Pathak, Pietro Maria Bertelli, Matthew D. Teasdale, Harriet Denton, Diya Bhattacharyya, Rafiqul Hussain, Jonathan M Coxhead, Joe Kelk, Kevin J. Marchbank, David Kavanagh, Marzena Kurzawa‐Akanbi, Lyle Armstrong, Reinhold J. Medina, Majlinda Lako
This study shows that the CFH Y402H variant makes choriocapillaris endothelial cells more susceptible to oxidative stress and complement dysregulation, linking these factors to AMD pathogenesis.
bioRxiv · Jun 19, 2026 · PreprintCell Biology