Matthew D. Teasdale

Transient Vascular Cell Integration and Intrinsic Media-Stimulated Endothelial Activation Reveal Diabetic Retinopathy Signatures in Human Retinal Organoids

The paper develops vascular organoids that integrate into retinal organoids, revealing diabetic retinopathy-like gene expression patterns in endothelial-like cells.

Xeno-free human iPSC-derived prostate organoid platform for multilineage differentiation and genetic manipulation

This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in CFH Y402H Patient-Derived Choriocapillaris Endothelial Cells

This study shows that the CFH Y402H variant makes choriocapillaris endothelial cells more susceptible to oxidative stress and complement dysregulation, linking these factors to AMD pathogenesis.

3,500 years of sheeppox virus evolution inferred from archaeological and codicological genomes

The paper reconstructs 3,500 years of sheeppox virus evolution using ancient genomes from archaeological and medieval parchment sources, showing divergence events and gene inactivation.

Exceptional ancient DNA preservation and fibre remains of a Sasanian saltmine sheep mummy in Chehrabad, Iran

The paper reports the whole genome sequencing of a 1600-year-old mummified sheep from a salt mine, showing exceptional DNA preservation and linking it to modern Southwest Asian breeds.

The York Gospels: a one thousand year biological palimpsest

The paper reports the first use of a non-invasive DNA sampling technique on the York Gospels to uncover a biological palimpsest spanning over 1,000 years.