Birthe Dorgau

The paper develops vascular organoids that integrate into retinal organoids, revealing diabetic retinopathy-like gene expression patterns in endothelial-like cells.

This study shows that rhythmic light flicker improves photoreceptor maturation in human retinal organoids by enhancing structural development, transcriptional transition, and functional connectivity.

STExplorer applies computational geography methods to spatial transcriptomics data to uncover spatially resolved patterns and heterogeneity.

This study presents the first single-cell spatio-temporal transcriptome of human retinal organoid development using single-cell RNA-Seq and spatial transcriptomics, revealing key developmental events and chromatin accessibility patterns.

This study shows that transplanted pluripotent stem cell-derived cone precursors can restore light responses in mice with advanced retinal degeneration, despite low engraftment.