Jonathan M Coxhead

This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

This study shows that the CFH Y402H variant makes choriocapillaris endothelial cells more susceptible to oxidative stress and complement dysregulation, linking these factors to AMD pathogenesis.

This study identifies non-canonical NF-κB signalling as a therapeutic target in CYLD cutaneous syndrome and shows that IKK inhibition reduces tumor viability in patient-derived models.

This study presents the first single-cell spatio-temporal transcriptome of human retinal organoid development using single-cell RNA-Seq and spatial transcriptomics, revealing key developmental events and chromatin accessibility patterns.

This study uses spatial transcriptomics to analyze human embryonic arterial valves, identifying novel genes and pathways involved in valve development and highlighting limitations in current genomic databases.

The paper identifies de novo mutations as a significant genetic cause of male infertility, finding several candidate genes and an enrichment of loss-of-function and missense mutations in intolerant genes.

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

This paper generates a single-cell atlas of the human cornea across development and disease, identifying key cell types, markers, and interactions that inform stem cell maintenance and disease mechanisms.

Spaniel is an R package for analyzing and sharing spatial transcriptomics data, addressing challenges in existing tools.