Rafiqul Hussain

Transient Vascular Cell Integration and Intrinsic Media-Stimulated Endothelial Activation Reveal Diabetic Retinopathy Signatures in Human Retinal Organoids

The paper develops vascular organoids that integrate into retinal organoids, revealing diabetic retinopathy-like gene expression patterns in endothelial-like cells.

Xeno-free human iPSC-derived prostate organoid platform for multilineage differentiation and genetic manipulation

This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in CFH Y402H Patient-Derived Choriocapillaris Endothelial Cells

This study shows that the CFH Y402H variant makes choriocapillaris endothelial cells more susceptible to oxidative stress and complement dysregulation, linking these factors to AMD pathogenesis.

Deciphering the spatio-temporal transcriptional and chromatin accessibility of human retinal organoid development at the single cell level

This study presents the first single-cell spatio-temporal transcriptome of human retinal organoid development using single-cell RNA-Seq and spatial transcriptomics, revealing key developmental events and chromatin accessibility patterns.

Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

A single cell atlas of human cornea that defines its development, limbal stem and progenitor cells and the interactions with the limbal niche

This paper generates a single-cell atlas of the human cornea across development and disease, identifying key cell types, markers, and interactions that inform stem cell maintenance and disease mechanisms.