Striatal Direct Pathway Targets Npas1+ Pallidal Neurons
Qiaoling Cui, Xixun Du, Isaac Y. M. Chang, Arin Pamukcu, Varoth Lilascharoen, Brianna L. Berceau, Daniela García, Darius Hong, Uree Chon, Ahana Narayanan, Yongsoo Kim, Byung Kook Lim, C. Savio Chan
This study identifies that direct-pathway striatal projection neurons (dSPNs) target Npas1+ neurons in the external globus pallidus (GPe) and show that this projection suppresses movement, contributing to Parkinson's disease hypokinesia.
Journal of Neuroscience · Mar 17, 2021Peer-reviewedNeuroscience