Isaac Y. M. Chang

The paper identifies two parallel GPe-to-nRT pathways with opposing effects on thalamic processing, mediated by region-specific KCC2 expression.

This study identifies distinct GPe neuron subtypes using mouse lines and shows their unique roles in motor behavior and anxiety-like behavior through optogenetics and machine learning.

This study identifies that direct-pathway striatal projection neurons (dSPNs) target Npas1+ neurons in the external globus pallidus (GPe) and show that this projection suppresses movement, contributing to Parkinson's disease hypokinesia.