Kruppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevity
Jorge Iván Castillo-Quan, Aiden McCarty, Ugne Kurdeikaite, Katherine Gilmore, Arlette Cabral, Justin Mejia, Julia Barrett, Maria La Terza, Emma Johnson, Allison Carroll, T. Keith Blackwell, Jean E. Schaffer, Natalie Moroz
This study identifies KLF-1 as an upstream regulator of SKN-1/Nrf transcription factors in C. elegans, linking lipid homeostasis, oxidative stress, and longevity.
bioRxiv · Nov 22, 2025 · PreprintCell Biology