Jorge Iván Castillo-Quan

This study identifies KLF-1 as an upstream regulator of SKN-1/Nrf transcription factors in C. elegans, linking lipid homeostasis, oxidative stress, and longevity.

The paper establishes international consensus criteria to classify ageing-related pathologies, diseases, and syndromes based on age progression, functional decline, and human evidence.

This study shows that enhancing autophagy through redox regulation extends lifespan in Drosophila by highlighting the role of a specific cysteine residue in Atg4a.

This study shows that Gba1 deletion in flies causes immune hyperactivation and microbial dysbiosis, which can be mitigated by microbiome modulation or autophagy stimulation.