Cell BiologybioRxivPreprint
Kruppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevity
Jorge Iván Castillo-Quan, Aiden McCarty, Ugne Kurdeikaite…·Natalie Moroz
This study identifies KLF-1 as an upstream regulator of SKN-1/Nrf transcription factors in C. elegans, linking lipid homeostasis, oxidative stress, and longevity.
DOI 10.1101/2025.11.22.689963