Mechanically-mediated low-pressure cell membrane poration enables tunable intracellular delivery of traditionally impermeable cargoes in high throughput and clinical scale formats
Sophia M. Hirsch, Darby Kreienberg, Zhihui Song, Alain Larocque, Yi Zuo, Rachel Conover, Eleni Jaecklein, Karen Gonzalez, Ain Imchen, Sean Franco, Michael A. Evans, R. Alexander Wesselhoeft, Matthew Swiatnicki, Hicham Zegzouti, Kirill Chesnov, , Armon Sharei
This paper introduces a mechanically-mediated low-pressure poration method for efficient, cargo-agnostic intracellular delivery with high throughput and clinical scalability.
bioRxiv · Aug 3, 2026 · PreprintCell Biology