Kirill Chesnov

This paper introduces a mechanically-mediated low-pressure poration method for efficient, cargo-agnostic intracellular delivery with high throughput and clinical scalability.

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

The paper develops engineered gap junction hemichannels to enable precise, long-term neural circuit editing in mammals by enabling communication between distinct cell types.

The paper shows that co-expressing NGN2 with EMX1 generates homogeneous glutamatergic neurons from human pluripotent stem cells, with altered transcriptional output and chromatin binding compared to NGN2 alone.