Author

Eleni Jaecklein

University of Massachusetts Chan Medical SchoolORCID 0000-0001-8744-5341Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Christopher M. SassettiiD· 2 shared David G. RusselliD· 2 shared Nelson V. SimwelaiD· 2 shared Ain Imchen· 1 shared Alain Larocque· 1 shared Alec Barclay· 1 shared Armon Sharei· 1 shared Cameron Pye· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

Christopher M. SassettiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Mechanically-mediated low-pressure cell membrane poration enables tunable intracellular delivery of traditionally impermeable cargoes in high throughput and clinical scale formats

Sophia M. Hirsch, Darby Kreienberg, Zhihui Song, Alain Larocque, Yi Zuo, Rachel Conover, Eleni Jaecklein, Karen Gonzalez, Ain Imchen, Sean Franco, Michael A. Evans, R. Alexander Wesselhoeft, Matthew Swiatnicki, Hicham Zegzouti, Kirill Chesnov, , Armon Sharei

This paper introduces a mechanically-mediated low-pressure poration method for efficient, cargo-agnostic intracellular delivery with high throughput and clinical scalability.

bioRxiv · Aug 3, 2026 · PreprintCell Biology

Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

Nelson V. Simwela, Eleni Jaecklein, Christopher M. Sassetti, David G. Russell

This study shows that impaired macrophage fatty acid metabolism limits Mycobacterium tuberculosis growth through multiple anti-microbial mechanisms.

eLife · Dec 16, 2024Peer-reviewedMicrobiology

Genome-wide screen of Mycobacterium tuberculosis-infected macrophages identified the GID/CTLH complex as a determinant of intracellular bacterial growth.

Nelson V. Simwela, Luana Johnston, Paulina Pavinski Bitar, Eleni Jaecklein, Craig Altier, Christopher M. Sassetti, David G. Russell

The paper identifies the GID/CTLH complex as a host determinant suppressing antimicrobial responses against intracellular bacterial infections through a CRISPR screen in Mtb-infected macrophages.

Nature Communications · Oct 29, 2024Peer-reviewedImmunology