Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunction
Tim V. D. van Tienhoven, Johanna Lepland, Anne de Snaijer, Akin Bucakci, Wout Maaskant, Gregory van Beek, Eric M. Bindels, Marc H.G.P. Raaijmakers, Tariq Enver, Valgarður Sigurðsson, Els Mansell
This paper shows that chemotherapy causes long-term bone marrow dysfunction by impairing hematopoietic stem cells, which can be reversed by mitochondrial-targeted treatment.
bioRxiv · Jul 18, 2025 · PreprintCell Biology