Metabolic cell death of labile iron deficiency as a vulnerability of head and neck squamous cancer cells evaded by BACH1
Masahiro Rokugo, Kazuki Nakamura, Mitsuyo Matsumoto, Akari Endo, Long C. Nguyen, Hironari Nishizawa, Ryohei Shima, Hitomi Kashiwagi, Akira Okoshi, Ayako Nakanome, Ryo Funayama, Keiko Nakayama, Takenori Ogawa, Takaaki Abe, Yukio Katori, Kazuhiko Igarashi
This study shows that BACH1 maintains labile iron levels in HNSCC cells, preventing metabolic cell death and enabling proliferation, and that BACH1 inhibition enhances the effect of tipifarnib.
bioRxiv · Apr 7, 2025 · PreprintCancer Biology