Kazuhiko Igarashi

This study identifies a BACH1-cMAF transcriptional axis that drives autoimmunity when SATB1 is lost, showing that targeting this axis can rescue disease.

This study shows that nuclear MAT2A activity is essential for antibody class switch recombination by maintaining AID expression after germline transcription.

This study shows that cysteine restriction induces ferroptosis in hepatic cancer cells via the polyamine biosynthetic pathway, but not in normal hepatocytes.

This study shows that BACH1 maintains labile iron levels in HNSCC cells, preventing metabolic cell death and enabling proliferation, and that BACH1 inhibition enhances the effect of tipifarnib.