Author

Hitomi Kashiwagi

Tohoku University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Takaaki AbeiD· 2 shared Yukio KatoriiD· 2 shared Akari Endo· 1 shared Akira Okoshi· 1 shared Alexander TyshkovskiyiD· 1 shared Ayako NakanomeiD· 1 shared Bohan ZhangiD· 1 shared Chika SaegusaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Takaaki AbeORCID

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2 papers

Recent·Most cited

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

Yohei Honkura, Takehiro Suzuki, Ryota Kujirai, Shin-ichiro Kanno, Yotaro Matsumoto, Yoshikazu Tanaka, Kowit Hengphasatporn, Satoru Nagatoishi, Alexander Tyshkovskiy, Tomoko Kasahara, Yoshiyasu Tongu, Bohan Zhang, Hitomi Kashiwagi, Chika Saegusa, Msato Fujioka, , Takaaki Abe

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

bioRxiv · Apr 18, 2025 · PreprintCell Biology

Metabolic cell death of labile iron deficiency as a vulnerability of head and neck squamous cancer cells evaded by BACH1

Masahiro Rokugo, Kazuki Nakamura, Mitsuyo Matsumoto, Akari Endo, Long C. Nguyen, Hironari Nishizawa, Ryohei Shima, Hitomi Kashiwagi, Akira Okoshi, Ayako Nakanome, Ryo Funayama, Keiko Nakayama, Takenori Ogawa, Takaaki Abe, Yukio Katori, Kazuhiko Igarashi

This study shows that BACH1 maintains labile iron levels in HNSCC cells, preventing metabolic cell death and enabling proliferation, and that BACH1 inhibition enhances the effect of tipifarnib.

bioRxiv · Apr 7, 2025 · PreprintCancer Biology