11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress
Kazuya Yabumoto, Yasuhiro M. Umemura, Hitomi Watanabe, Yasuhiro Endo, Nobuya Koike, Akiyo Kakibuchi, Akira Sugimoto, Taisuke Mori, Gen Kondoh, Kazuhiro Yagita
This study shows that 11β-HSD2 buffers maternal glucocorticoid surges during early development, preventing premature circadian clock activation and segmentation defects.
PNAS Nexus · Aug 24, 2026Peer-reviewedDevelopmental Biology