Michael E. Baker

The paper compares the transcriptional activation of estrogen receptors by estrone, estradiol, and estriol in different cell lines and species, finding that estriol can be more active than estradiol under certain conditions.

This study compares the transcriptional activation of human MR haplotypes (Val-180 vs. Ile-180) by corticosteroids in HEK293 cells using different promoters, finding differences in EC50 and fold-activation.

The paper studies estrogen receptor activation in elephant shark, finding three active ER genes and one unresponsive gene, with similar estrogen responses to humans.

This study identifies novel human mineralocorticoid receptor variants not found in chimpanzees, gorillas, or orangutans, suggesting evolutionary divergence in MR function.

This study compares the transcriptional activation of two human mineralocorticoid receptor variants by aldosterone, finding increased activation in MR-988 with KCSW in the DNA-binding domain.

The paper investigates steroid responses of mineralocorticoid receptors in Amur sturgeon and tropical gar, finding lower EC50s compared to human and zebrafish MRs, suggesting different agonist mechanisms.