Interleukin-33 coordinates a microglial phagocytic response and limits corticothalamic excitability and seizure susceptibility
Rafael Taeho Han, Ilia D. Vainchtein, Johannes C. M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Tessa Johung, Eunji Ahn, Jerika J. Barron, Hiromi Nakao-Inoue, Akshaj Joshi, Ari B. Molofsky, Christopher K. Glass, Jeanne T. Paz, Anna Victoria Molofsky
This study identifies IL-33's role in microglial phagocytosis and its impact on synaptic refinement and seizure susceptibility in the developing brain.
bioRxiv · Aug 5, 2021 · PreprintNeuroscience