Leah C. Dorman

The paper presents a multimodal perturbation atlas using CRISPR knockouts in A549 cells, combining microscopy, phase imaging, and scRNA-seq to assess phenotypic resolution.

This study compares five RNA velocity methods across three datasets to evaluate their performance in predicting cellular states.

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

This study uses a dengue replicon model to show how host pathways are rewired to support persistent RNA replication without stress responses.

This study uses single-cell RNA sequencing to show that M. tuberculosis ESX-1 promotes the recruitment and differentiation of anti-inflammatory macrophages in infected mouse lungs.

The paper shows type 1 lymphocytes produce interferon-γ in the thalamus after brain injury, reducing seizure susceptibility by limiting neural hyperexcitability.

This study shows that group 2 innate lymphoid cells (ILC2s) and their cytokine IL-13 promote inhibitory synapse development and adult social behavior.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

This study uses single-nucleus RNA sequencing to analyze a mouse glioblastoma model, identifying potential therapeutic targets and similarities with human GBM subtypes.

The paper provides a framework and interactive software tools for manually annotating cell types in single-cell multi-omics datasets, demonstrating how different modalities can be combined to improve annotation accuracy.

The paper identifies distinct microglial subsets in zebrafish brains that perform different phagocytic functions using single-cell RNA sequencing and spatial analysis.

This study identifies IL-33's role in microglial phagocytosis and its impact on synaptic refinement and seizure susceptibility in the developing brain.