Jeanne T. Paz

This study shows that Semaphorin-3A supports sleep and cognitive resilience after brain injury by maintaining sleep architecture and memory consolidation.

The paper identifies two parallel GPe-to-nRT pathways with opposing effects on thalamic processing, mediated by region-specific KCC2 expression.

This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.

The paper shows that visual signals reach the hippocampus through a conserved midbrain pathway, enabling spatial maps even after visual cortex ablation.

The paper identifies a dual inhibitory network in the thalamic reticular nucleus (TRN) involving intra-TRN and pallidal inputs, revealing subtype-specific connectivity and complementary mechanisms for thalamic signal gating.

This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

This paper introduces a novel mouse model of central post-stroke pain (CPSP) using photothrombotic ischemia in the thalamus, showing persistent facial grimace pain and correlating microglial activation with pain severity.

This study shows that exposure to anti-GluN1 mAb during development causes long-term sensory-motor deficits and callosal axon changes in mice.

The paper shows type 1 lymphocytes produce interferon-γ in the thalamus after brain injury, reducing seizure susceptibility by limiting neural hyperexcitability.

This paper creates a PTHS mouse model with astrocyte-specific Tcf4 knockout, showing seizures, astrogliosis, increased neuronal activity, and gene expression changes.

The paper develops an algorithm to predict general anesthesia overdose by analyzing EEG transition phases in mice, identifying key patterns that anticipate overdose several minutes in advance.

This paper describes a novel mouse model of SLC6A1 mutation-associated neurodevelopmental epilepsy, showing seizure burden correlates with behavioral deficits and drug responses.

This study shows that C1q mediates chronic neuron loss and inflammation after brain injury by targeting the corticothalamic circuit in mice.

This study identifies IL-33's role in microglial phagocytosis and its impact on synaptic refinement and seizure susceptibility in the developing brain.

The paper shows that somatostatin-positive neurons in the reticular thalamus modulate visual information and gamma activity in V1 and dLGN in behaving mice.