SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts.
Mehdi Denis Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah van Tol, Paulina Rudolffi-Soto, Christian S. Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David A. Jacques, Benhur Lee, Emma Sierecki, Yann Gambin
This study identifies SARS-CoV-2 proteases NSP3 and NSP5 cleaving IRF3, NLRP12, and TAB1, which modulate inflammatory pathways, and explores implications for disease across species and potential reservoir hosts.
Emerging Microbes & Infections · Dec 29, 2020Peer-reviewedMolecular Biology