Molecular BiologyEmerging Microbes & InfectionsPeer-reviewed
SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts.
Mehdi Denis Moustaqil, Emma Ollivier, Hsin-Ping Chiu…·Yann Gambin
This study identifies SARS-CoV-2 proteases NSP3 and NSP5 cleaving IRF3, NLRP12, and TAB1, which modulate inflammatory pathways, and explores implications for disease across species and potential reservoir hosts.