Sarah van Tol

A Synthetic Consensus Chiroptera IFN-β Induces IFN-I Signaling Across Diverse Bat Taxa

The paper designs a synthetic consensus IFN-β for bats that induces IFN-I signaling across diverse bat species, enabling study of antiviral immunity.

Jamaican fruit bats are susceptible to henipaviruses but rapidly control infection

This study shows Jamaican fruit bats are susceptible to henipaviruses but rapidly control infection following oral exposure.

Lower pathogenicity but similar genital shedding of monkeypox virus clade Ib compared to clade Ia in a rodent model

Highly efficient anogenital transmission of clade Ia mpox virus associated with increased shedding.

This study investigates mpox virus transmission in prairie dogs, finding that anogenital mucosal routes lead to high shedding and efficient transmission.

Enhanced encephalitic tropism of bovine H5N1 compared to the Vietnam H5N1 isolate in mice

This study compares the tissue tropism of two HPAI H5N1 isolates in mice, finding that the bovine isolate replicates in the brain and causes more neurotropism and inflammation than the human isolate.

Jamaican fruit bats (Artibeus jamaicensis) competence for Ebola virus but not Marburg virus is driven by intrinsic differences in viral entry and IFN-I signaling antagonism.

This study shows Jamaican fruit bats can support EBOV replication and shedding but not MARV, due to differences in viral entry and IFN-I signaling suppression.

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

This study evaluates the fitness and pathogenesis of Omicron variants in the upper and lower respiratory tracts, finding increased URT fitness with reduced lung pathology.

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts.

This study identifies SARS-CoV-2 proteases NSP3 and NSP5 cleaving IRF3, NLRP12, and TAB1, which modulate inflammatory pathways, and explores implications for disease across species and potential reservoir hosts.