P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy
Luis Alejandro Rojas, Erin Valentine, Anthony Accorsi, Joseph Maglio, Ning Shen, Alan Robertson, Steven L. Kazmirski, Peter B. Rahl, Rabi Tawil, Diego Cadavid, Lorin A. Thompson, Lucienne V. Ronco, Aaron N. Chang, Angela M. Cacace, Owen B. Wallace
This study identifies p38 as a regulator of DUX4 expression in FSHD, showing that p38 inhibitors reduce DUX4 and cell death in patient-derived myotubes.
Journal of Pharmacology and Experimental Therapeutics · Jun 23, 2020Peer-reviewedDevelopmental Biology