Luis Alejandro Rojas

This study shows that elevated alpha-synuclein in neurons reduces microglial phagocytosis in a co-culture model derived from SNCA triplication iPSCs.

The paper shows that in fragile X syndrome, long-range heterochromatinization of distal synaptic genes with STR instability is reversible by overexpression of a pre-mutation-length CGG tract.

This study identifies p38 as a regulator of DUX4 expression in FSHD, showing that p38 inhibitors reduce DUX4 and cell death in patient-derived myotubes.