Author

Aaron N. Chang

Cambridge Intellectual Property (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Angela M. CacaceiD· 2 shared Owen B. WallaceiD· 2 shared Alan Robertson· 1 shared Alexandra Corella· 1 shared Alicia Zhou· 1 shared Andrei GogaiD· 1 shared Andrew S. KhaliliD· 1 shared Anthony Accorsi· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Angela M. CacaceORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Fragile X syndrome patient-derived neurons developing in the mouse brain show FMR1 -dependent phenotypes

Marine Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Andrew S. Khalil, Tenzin Lungjangwa, Jennifer Shih, Aaron N. Chang, Stephen T. Warren, Angela M. Cacace, Kristin R. Andrykovich, Rosalie G. J. Rietjens, , Rudolf Jaenisch

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

Biological Psychiatry · Jan 1, 2023Peer-reviewedNeuroscience

P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy

Luis Alejandro Rojas, Erin Valentine, Anthony Accorsi, Joseph Maglio, Ning Shen, Alan Robertson, Steven L. Kazmirski, Peter B. Rahl, Rabi Tawil, Diego Cadavid, Lorin A. Thompson, Lucienne V. Ronco, Aaron N. Chang, Angela M. Cacace, Owen B. Wallace

This study identifies p38 as a regulator of DUX4 expression in FSHD, showing that p38 inhibitors reduce DUX4 and cell death in patient-derived myotubes.

Journal of Pharmacology and Experimental Therapeutics · Jun 23, 2020Peer-reviewedDevelopmental Biology

MYC Dysregulates Mitotic Spindle Function Creating a Dependency on TPX2

Julia Rohrberg, Alexandra Corella, Moufida Taileb, Seda Kilinc, Marie-Lena Jokisch, Roman Camarda, Alicia Zhou, Sanjeev Balakrishnan, Aaron N. Chang, Andrei Goga

This study shows MYC dysregulates mitotic spindle function, creating a dependency on TPX2, and identifies a synthetic-lethal interaction between MYC and TPX2 in cancers.

bioRxiv · Apr 5, 2018 · PreprintCell Biology