Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Jonathan S. Brammeld, Mia Petljak, Iñigo Martincorena, Steven P. Williams, Luz García‐Alonso, Alba Dalmases, Beatríz Bellosillo, Carla Daniela Robles‐Espinoza, Stacey Price, Syd Barthorpe, Patrick S. Tarpey, Constantine Alifrangis, Graham R. Bignell, Joana Vidal, Jamie Young, , Ultan McDermott
This paper describes a method to identify drug resistance mutations in cancer using genome-wide chemical mutagenesis and next-generation sequencing, enabling the discovery of both known and novel resistance mechanisms.
Genome Research · Apr 1, 2017Peer-reviewedGenetics