Syd Barthorpe

On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells.

This study identifies on-target WRN mutations as resistance mechanisms in MSI cancer cells to WRN helicase inhibitors and suggests combination therapies to prevent resistance.

Pan-cancer proteomic map of 949 human cell lines reveals principles of cancer vulnerabilities

The paper presents a pan-cancer proteomic map of 949 cell lines, revealing protein-specific biomarkers of cancer vulnerabilities and showing proteomic data's superior predictive power for drug response.

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

This paper describes a method to identify drug resistance mutations in cancer using genome-wide chemical mutagenesis and next-generation sequencing, enabling the discovery of both known and novel resistance mechanisms.