Author

Steven P. Williams

Wellcome Sanger InstituteORCID 0000-0002-9382-4337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Julio Sáez-RodrígueziD· 2 shared Stacey Price· 2 shared Ultan McDermottiD· 2 shared Alba Dalmases· 1 shared Alvis BrāzmaiD· 1 shared Beatríz BellosilloiD· 1 shared Carla Daniela Robles‐EspinozaiD· 1 shared Clara AlsinetiD· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersSystems Biology

Julio Sáez-RodríguezORCID

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2 papers

Recent·Most cited

Genomic determinants of protein abundance variation in colorectal cancer cells

Theodoros I. Roumeliotis, Steven P. Williams, Emanuel Gonçalves, Clara Alsinet, Martin Del Castillo Velasco‐Herrera, Nanne Aben, Fatemeh Zamanzad Ghavidel, Magali Michaut, Michaël Schubert, Stacey Price, James C. Wright, Lu Yu, Mi Yang, Rodrigo Dienstmann, Justin Guinney, , Jyoti Sharma Choudhary

The paper quantifies proteomic and genomic variation in colorectal cancer cell lines to understand how mutations affect protein levels and drug responses.

Cell Reports · Aug 1, 2017Peer-reviewedSystems Biology

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Jonathan S. Brammeld, Mia Petljak, Iñigo Martincorena, Steven P. Williams, Luz García‐Alonso, Alba Dalmases, Beatríz Bellosillo, Carla Daniela Robles‐Espinoza, Stacey Price, Syd Barthorpe, Patrick S. Tarpey, Constantine Alifrangis, Graham R. Bignell, Joana Vidal, Jamie Young, , Ultan McDermott

This paper describes a method to identify drug resistance mutations in cancer using genome-wide chemical mutagenesis and next-generation sequencing, enabling the discovery of both known and novel resistance mechanisms.

Genome Research · Apr 1, 2017Peer-reviewedGenetics