Author

Graham R. Bignell

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Ultan McDermottiD· 3 shared Francesco IorioiD· 2 shared Iñigo MartincorenaiD· 2 shared Mathew J. GarnettiD· 2 shared Patrick S. TarpeyiD· 2 shared Abel DevadassiD· 1 shared Adam M. H. Young· 1 shared Adrienne Margaret FlanaganiD· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenomics

Ultan McDermottORCID

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Author profile →

4 papers

Recent·Most cited

PGP-UK: a research and citizen science hybrid project in support of personalized medicine

Stephan Beck, Alison Berner, Graham R. Bignell, Maggie Bond, M Callanan, Olga Chervova, Lucía Conde, Manuel Corpas, Simone Ecker, Hannah R. Elliott, Silvana A. Fioramonti, Adrienne Margaret Flanagan, Ricarda Gaentzsch, David G. Graham, Deirdre Gribbin, , John N. Wood

PGP-UK explores citizen science in genomics by recruiting participants, sharing data, and developing tools to advance personalized medicine.

BMC Medical Genomics · Nov 27, 2018Peer-reviewedGenomics

An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

Grace Collord, Patrick S. Tarpey, Natalja Kurbatova, Iñigo Martincorena, Sebastián Morán, Manuel Castro de Moura, Tibor Nagy, Graham R. Bignell, Francesco Maura, Matthew D. Young, Jorge Berna, José M. C. Tubío, Christopher E McMurran, Adam M. H. Young, Mathijs Arnoud Sanders, , Ultan McDermott

This study identifies two molecular subgroups of anaplastic meningioma with distinct survival outcomes and links them to specific genetic mutations.

Scientific Reports · Sep 4, 2018Peer-reviewedGenomics

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

Marco Ranzani, Kristel Kemper, Magali Michaut, Oscar Krijgsman, Nanne Aben, Vivek Iyer, Kim Wong, Theodoros I. Roumeliotis, Martin Del Castillo Velasco-Herrera, Jérémie Nsengimana, Gemma Turner, Nicola Thompson, Aida Shahrabi, Marcela Sjoberg, Mamunur Rashid, , David J. Adams

bioRxiv · Sep 28, 2017 · PreprintCancer Biology

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Jonathan S. Brammeld, Mia Petljak, Iñigo Martincorena, Steven P. Williams, Luz García‐Alonso, Alba Dalmases, Beatríz Bellosillo, Carla Daniela Robles‐Espinoza, Stacey Price, Syd Barthorpe, Patrick S. Tarpey, Constantine Alifrangis, Graham R. Bignell, Joana Vidal, Jamie Young, , Ultan McDermott

This paper describes a method to identify drug resistance mutations in cancer using genome-wide chemical mutagenesis and next-generation sequencing, enabling the discovery of both known and novel resistance mechanisms.

Genome Research · Apr 1, 2017Peer-reviewedGenetics