Cannabidiol targets a modulatory system for excitatory-inhibitory synaptic coordination, contributing to its anti-seizure action
Evan C. Rosenberg, Simon Chamberland, Michaël Bazelot, Erica R. Nebet, Xiaohan Wang, Sam McKenzie, Swati S. Jain, Stuart Greenhill, Max A Wilson, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simón D. Sun, , Richard W. Tsien
This study investigates how CBD modulates LPI-GPR55 signaling at excitatory and inhibitory synapses, showing its role in reducing seizure activity by blocking LPI's pro-excitatory effects and enhancing inhibitory synaptic strength.
bioRxiv · Sep 27, 2022 · PreprintNeuroscience