György Buzsáki

Hippocampal and prefrontal contributions to memory-guided navigation depend on task epoch

This study investigates the role of hippocampus and prefrontal cortex in memory-guided navigation by testing their contribution during different task phases in mice.

Subspace communication in the hippocampal-retrosplenial axis

The paper identifies communication subspaces in the hippocampal-retrosplenial circuit using partial canonical correlation analysis, showing how these subspaces reconfigure to support flexible encoding of experiences.

Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation

The paper shows that hippocampal sharp wave-ripple clusters enhance network segregation and replay of spatial trajectories during memory consolidation.

Non-invasive modulation of brain activity and behavior by transcranial radio frequency stimulation

This paper introduces TRFS, a non-invasive brain stimulation technique using RF energy to modulate neural activity and behavior in mice, showing both suppression and excitation effects depending on the mode.

From labels to latents: revealing state-dependent hippocampal computations and non-spatial replay with Jump Latent Variable Model

This paper introduces a latent variable model to analyze hippocampal activity without external labels, revealing continuity-fragmentation dynamics and non-spatial replay in rodent behavior.

Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans

This study identifies spatiotemporal patterns distinguishing hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans, introducing a detection tool for improved analysis.

Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals

This paper introduces two TEMPO voltage-sensing technologies to image high-frequency neural oscillations in behaving mammals, revealing new insights into excitatory-inhibitory dynamics and wave propagation.

ThermoMaze: A behavioral paradigm for readout of immobility-related brain events

The paper introduces ThermoMaze, a behavioral paradigm that enables the study of brain activity during immobility by leveraging mice's warmth-seeking behavior and combines it with electrophysiology.

Inhibitory and disinhibitory VIP IN-mediated circuits in neocortex

The paper identifies four distinct VIP interneuron populations in the neocortex with unique connectivity and responses to neuromodulation, showing specialized roles in cortical circuit regulation.

Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations

The paper investigates bidirectional interactions between hippocampal sharp wave ripples and neocortical slow oscillations during sleep using electrophysiology and imaging in mice.

Hippocampal neuronal activity is aligned with action plans

This study investigates how hippocampal neurons in mice encode different variables during a task, finding that spiking activity aligns with internal action plans rather than external cues.

Perpetual step-like restructuring of hippocampal circuit dynamics

The paper shows that hippocampal neurons exhibit step-like changes in place fields, suggesting pre-existing assemblies are reused rather than new fields being formed.

Dual-color micro-LEDs integrated neural interface for multi-control optogenetic electrophysiology

This paper develops a dual-color micro-LED neural interface for optogenetic electrophysiology, enabling bidirectional control and recording in vivo.

Self-Assembled Origami Neural Probes for Scalable, Multifunctional, Three-Dimensional Neural Interface

This paper introduces self-assembled origami neural probes that enable scalable, multifunctional, and 3D neural interfaces with integrated sensors and optogenetic capabilities.

Selection of experience for memory by hippocampal sharp wave ripples

The paper shows that hippocampal sharp wave ripples (SPW-Rs) during wakefulness tag experiences for memory consolidation by replaying the most reactivated trials during sleep.

Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity

The paper shows that synaptic homeostasis uses both Hebbian and homeostatic mechanisms in a nonmonotonic way to adapt to prolonged inactivity.

Brain-implanted conductors amplify radiofrequency fields in rodents: advantages and risks

This study examines how brain implants in rodents amplify radiofrequency fields, causing neuronal firing and temperature increases without heat injury, highlighting safety concerns and potential neurostimulation applications.

Id2 GABAergic interneurons: a neglected fourth major group of cortical inhibitory cells

The paper identifies a fourth major group of cortical inhibitory neurons, Id2 GABAergic interneurons, characterized by neurogliaform cells and distinct electrophysiological properties.

Intricate epileptiform discharges affect memory in an Alzheimer's Disease mouse model

The paper investigates how interictal epileptiform discharges (IEDs) affect memory in Alzheimer's Disease mice, finding that IEDs disrupt hippocampal activity and correlate with impaired memory.

Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons

The paper shows that brief synaptic inhibition can persistently silence fast-spiking interneurons for hundreds of milliseconds, impacting circuit function through disinhibition of pyramidal cells.

Cannabidiol targets a modulatory system for excitatory-inhibitory synaptic coordination, contributing to its anti-seizure action

This study investigates how CBD modulates LPI-GPR55 signaling at excitatory and inhibitory synapses, showing its role in reducing seizure activity by blocking LPI's pro-excitatory effects and enhancing inhibitory synaptic strength.

Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis

The paper shows that hippocampal network dynamics in adult mice are shaped by the birthdate and rate of neurogenesis during embryonic development.

Closed-loop brain stimulation to reduce pathologic fear

This study shows that closed-loop brain stimulation using hippocampal sharp wave-ripples can enhance fear extinction memory consolidation and reduce pathologic fear in a PTSD model.

Brain temperature affects quantitative features of hippocampal sharp wave ripples

This study shows that brain temperature in the hippocampal CA1 region influences ripple frequency but not other SPW-R parameters.

Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression

The paper shows that restoring gamma oscillations in the limbic system via olfactory bulb neuromodulation alleviates depressive-like behaviors in animals.

Distinct ground state and activated state modes of spiking in forebrain neurons

The paper identifies two distinct spiking modes in forebrain neurons: a universal ground state and context-dependent activated state, with implications for neuronal function.

A transient postnatal quiescent period precedes emergence of mature cortical dynamics

The paper identifies a transient quiescent period in early postnatal development that precedes the emergence of mature cortical dynamics in mice and humans.

Metal microdrive and head cap system for silicon probe recovery in freely moving rodent

The paper introduces a recoverable and reusable microdrive and head cap system for silicon probe recovery in freely moving rodents, reducing cost and experimental complexity.

Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing

This study examines how interictal epileptiform discharges (IEDs) affect memory during encoding and retrieval, finding they reduce memory success and disrupt hippocampal ripples.

Preexisting hippocampal network dynamics constrain optogenetically induced place fields

This study shows that preexisting hippocampal network dynamics constrain the formation of novel place fields induced by optogenetic stimulation.