The centromere localization domain of kinetoplastid kinetochore protein KKT2 recognizes the free N-terminus of histone H3
Aleksandra Ciszek, Patryk Ludzia, Gabriele Marcianò, William L. Allen, Midori Ishii, Sam Forsyth, Christopher W. Wood, Christina Redfield, Bungo Akiyoshi
This study shows that the KKT2 CL domain binds histone H3 N-terminus and that methylation of this region disrupts binding, suggesting a mechanism for kinetochore assembly in kinetoplastids.
bioRxiv · Aug 18, 2026 · PreprintCell Biology