Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated SMAD2 mutations
Rohan Bhattacharya, Tarsha L. Ward, Titilola D. Kalejaiye, Alekshyander Mishra, Sophia M. Leeman, Hamidreza Arzaghi, Jonathan G. Seidman, Christine E. Seidman, Samira Musah
This study uses engineered human iPSCs to show that SMAD2 mutations linked to CHD disrupt kidney podocytogenesis and glomerular structure, leading to proteinuria.
Nature Biomedical Engineering · Nov 3, 2025Peer-reviewedBioengineering