Author

Sophia M. Leeman

Duke UniversityORCID 0009-0008-0118-280XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alekshyander Mishra· 2 shared Rohan BhattacharyaiD· 2 shared Samira MusahiD· 2 shared Titilola D. KalejaiyeiD· 2 shared Christine E. SeidmaniD· 1 shared Christopher John SperatiiD· 1 shared Daniel Silas· 1 shared Gentzon HalliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBioengineering

Alekshyander Mishra

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedNov 3, 2025

Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated SMAD2 mutations

Rohan Bhattacharya, Tarsha L. Ward, Titilola D. Kalejaiye…·Samira Musah

This study uses engineered human iPSCs to show that SMAD2 mutations linked to CHD disrupt kidney podocytogenesis and glomerular structure, leading to proteinuria.

9 citations

humanscRNA-seq

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GeneticsbioRxivPreprintFeb 11, 2025

A Novel TRPC6 Mutation Causes Autosomal Dominant FSGS

Rohan Bhattacharya, Xingrui Mou, Sophia M. Leeman…·Samira Musah

The paper reports a novel TRPC6 mutation causing autosomal dominant FSGS and shows that combined Sildenafil and Losartan therapy improves podocyte dysfunction.

1 citation

humanexperimental assay

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