Author

Christopher John Sperati

Johns Hopkins UniversityORCID 0000-0002-8409-0714Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Gentzon HalliD· 2 shared Alekshyander Mishra· 1 shared Amanda L. KnoteniD· 1 shared Avi Z. RosenbergiD· 1 shared Benjamin SempowskiiD· 1 shared Chirag R. ParikhiD· 1 shared Daniel Flores-GuerreroiD· 1 shared Daniel Silas· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

Gentzon HallORCID

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Author profile →

4 papers

Recent·Most cited

CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes

Yingyu Sun, Nils Michael Kronenberg, Sidharth Kumar Sethi, Surjya Narayan Dash, Maria E. Kovalik, Benjamin Sempowski, Shelby Strickland, Rupesh Raina, Christopher John Sperati, Xuefei Tian, Shuta Ishibe, Gentzon Hall, Malte C. Gather

This study shows CRB2 deficiency in podocytes increases YAP signaling and disrupts mechanosensing, leading to enhanced contractility and altered focal adhesion.

American Journal of Physiology-Renal Physiology · Mar 10, 2025Peer-reviewedBiophysics

A Novel TRPC6 Mutation Causes Autosomal Dominant FSGS

Rohan Bhattacharya, Xingrui Mou, Sophia M. Leeman, Alekshyander Mishra, Titilola D. Kalejaiye, Megan Stangl, Daniel Silas, Karen L. Soldano, Christopher John Sperati, Opeyemi A. Olabisi, Gentzon Hall, Samira Musah

The paper reports a novel TRPC6 mutation causing autosomal dominant FSGS and shows that combined Sildenafil and Losartan therapy improves podocyte dysfunction.

bioRxiv · Feb 11, 2025 · PreprintGenetics

Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome

Michael Cole, Nikhil Ranjan, Gloria Frances Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, George T McNamara, Shruti Chaturvedi, Christopher John Sperati, Keith R. McCrae, Robert Alan Brodsky

The paper develops complement biosensors to identify classical pathway stimulation in CM-HUS, revealing IgM-driven mechanisms in patients lacking alternative pathway variants.

Blood · Oct 2, 2024Peer-reviewedImmunology

Single Nucleus RNA Sequencing of Remnant Kidney Biopsies and Urine Cell RNA Sequencing Reveal Cell Specific Markers of Covid-19 Acute Kidney Injury

Reetika R. Ghag, Madhurima Kaushal, Gerald Nwanne, Amanda L. Knoten, Krzysztof Kiryluk, Avi Z. Rosenberg, Steven P. Menez, Serena Maria Bagnasco, Christopher John Sperati, Mohamed G. Atta, Joseph P. Gaut, James C. Williams, Tarek M. El‐Achkar, Lois Johanna Arend, Chirag R. Parikh, Sanjay R. Jain

bioRxiv · Nov 10, 2023 · PreprintGenetics