Titilola D. Kalejaiye

In rat hippocampal neurons under mild oxidative stress, Optineurin-marked damaged mitochondria are engulfed slowly and reach lysosomes over days; scavenging mitochondrial reactive oxygen species or nutrient deprivation speeds this.

This study uses engineered human iPSCs to show that SMAD2 mutations linked to CHD disrupt kidney podocytogenesis and glomerular structure, leading to proteinuria.

The paper reports a novel TRPC6 mutation causing autosomal dominant FSGS and shows that combined Sildenafil and Losartan therapy improves podocyte dysfunction.