Reversible hypervascularization drives cognitive decline and blood-brain barrier damage during aging
Mihail Ivilinov Todorov, Katalin Völgyi, David‐Paul Minde, Saketh Kapoor, Mayar Ali, Rainer Malik, Johannes Christian Paetzold, Julian McGinnis, Lanyue Zhang, Alessia Nottebrock, Lu Liu, Mikael Simons, Harsharan S. Bhatia, Marios K. Georgakis, Martin Dichgans, , Ali Ertürk
The paper identifies a hypervascular, BBB-compromised state in aging mice linked to cognitive decline and shows pharmacological stabilization improves vascular and cognitive outcomes.
bioRxiv · May 6, 2026 · PreprintNeuroscience