The paper identifies a hypervascular, BBB-compromised state in aging mice linked to cognitive decline and shows pharmacological stabilization improves vascular and cognitive outcomes.

bioRxiv · May 6, 2026 · PreprintNeuroscience

Neutrophils are critical for placental and fetal infection with the human pathogen Listeria monocytogenes

Myriam Ripphahn, Nikita Raj, Hellen Cristina Ishikawa-Ankerhold, Zhouyi Rong, Bastian Popper, Bianca Portugal Tavares de Moraes, Xia Li, Ying Chen, Anne Kathrin Lößlein, Lou Martha Wackerbarth, Dominic Adam van den Heuvel, Barbara Schmidinger, Rainer Haas, Udo Jeschke, Sven Kehl, , Markus Sperandio

The paper identifies maternal neutrophils as a survival niche for Listeria monocytogenes, facilitating placental and fetal infection during pregnancy.

bioRxiv · Mar 18, 2026 · PreprintImmunology

Aging reprograms the response to chronic stress

G x FC nter Stein, Mihail Ivilinov Todorov, Lisa De Lange, Konstantin Riege, Emilio Cirri, Iqra Hussain, Martina Korfei, Nadine Pömpner, Christian Andreas Hübner, Karl Lenhard Rudolph, Farida Hellal, Ali Ertürk, Steve Hoffmann, Olivia Engmann

This study shows that chronic stress accelerates brain aging in young mice but activates age-specific anti-aging programs in old mice.

bioRxiv · Feb 17, 2026 · PreprintNeuroscience

LipiGo: A Versatile DNA-Lipid Nanoparticle Hybrid for Precision Drug Delivery

Karoline Kadletz, Ceren Kımna, Valentin Kenneth Reichenbach, Olga Carofiglio, Denise Jeridi, Igor Khalin, Ying Chen, Izabela Horvath, David‐Paul Minde, Mayar Ali, Taras Sych, Sofia Hu, Luciano Hoeher, Eren Aydeniz, Yagmur Ayse Kulcu, , Ali Ertürk

LipiGo is a DNA-lipid nanoparticle hybrid that enables efficient delivery of functional mRNA to non-hepatic tissues, particularly the spleen, through passive redistribution and active targeting.

bioRxiv · Sep 15, 2025 · PreprintBioengineering

Deep Learning and 3D Imaging Reveal Whole-Body Alterations in Obesity

Doris Kaltenecker, Izabela Horvath, Rami Al-Maskari, Zeynep Ilgin Kolabas, Ying Chen, Luciano Hoeher, Mihail Ivilinov Todorov, Saketh Kapoor, Mayar Ali, Florian Kofler, Pauline Morigny, Julia Geppert, Denise Jeridi, Carolina Cigankova, Victor Miro Kolenic, , Ali Ertürk

This paper introduces MouseMapper, a deep learning tool combined with 3D imaging to analyze whole-body structural changes in obesity, revealing nerve and immune system alterations.

bioRxiv · Aug 18, 2024 · PreprintSystems Biology

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19

Zhouyi Rong, Hongcheng Mai, Saketh Kapoor, Victor G. Puelles, Jan Czogalla, Julia Schädler, Jessica Vering, Claire Delbridge, Hanno Steinke, Hannah Frenzel, Katja Schmidt, Özüm Şehnaz Çalışkan, Jochen Martin Wettengel, Fatma Cherif, Mayar Ali, , Ali Ertürk

This study shows SARS-CoV-2 spike protein accumulates in the skull-meninges-brain axis, causing brain cell death and long-term neurological effects.

bioRxiv · Apr 4, 2023 · PreprintNeuroscience