NeurosciencebioRxivPreprint
Neuronal NADPH oxidase in Parkinson disease pathogenesis
Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer…·Roberto Di Maio
The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.
DOI 10.1101/2021.05.13.443999